Dermatofibrosarcoma protuberans aggravated during pregnancy: a case report and literature review
10.3760/cma.j.cn114453-20220525-00161
- VernacularTitle:妊娠期迅速增大的隆突性皮肤纤维肉瘤1例及文献复习
- Author:
Mengna JIA
1
;
Shuo ZHANG
;
Shuhan ZHAO
;
Xiaohan SUN
;
Peijun SONG
;
Jing XU
Author Information
1. 蚌埠医学院第一附属医院整形外科，蚌埠 233099
- Keywords:
Dermatofibrosarcoma;
Pregnancy;
Sarcoma
- From:
Chinese Journal of Plastic Surgery
2023;39(11):1251-1254
- CountryChina
- Language:Chinese
-
Abstract:
Dermatofibrosarcoma protuberans ( DFSP ) is very rare in clinic, and its diagnosis is not specific. According to the literature domestic and abroad, only 18 cases of patients during gestation period suffered from DFSP have been reported. This paper reported a case from the Department of Plastic Surgery, the First Affiliated Hospital of Bengbu Medical College in April 2022 diagnosed with DFSP during pregnancy.The DFSP showed rapid growth and pain during pregnancy, and stopped rapid growth after delivery. Extensive local resection was performed and the incision margin exceeded 3 cm diameter of the tumor. One-stage skin graft was used to repair the defect. HE staining showed a single spindle cell, arranged in a vortex, with large and dark nuclei. Some nuclei were heteromorphic, and few mitotic figures were observed. Postoperative pathology showed negative margins and basement. Immunohistochemistry showed CD34 (+ + ), Ki-67 (+, 10% ), bcl-2 (-), s-100 (-), SMA (-), CD163 (-), CD68 (-), which were consistent with the diagnosis of DFSP. The pathogenesis of DFSP is not yet clear. As a special population, patients during gestation period need special treatment and diagnosis. Through literature review, this paper summarizes the reports domestic and abroad, and discusses the diagnosis, treatment and prognosis of patients with DFSP during pregnancy.
