Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios.
10.3349/ymj.2009.50.2.304
- Author:
Hanik K YOO
1
;
Seockhoon CHUNG
;
Jin Pyo HONG
;
Boong Nyun KIM
;
Soo Churl CHO
Author Information
1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Autism spectrum disorders;
genetics;
transmission disequilibrium test;
microsatellite;
gamma-aminobutyric acid-A receptor subunit beta3
- MeSH:
Adult;
Asian Continental Ancestry Group/*genetics;
Autistic Disorder/*genetics;
Child;
Child, Preschool;
Female;
Genetic Predisposition to Disease;
Humans;
Infant;
Korea;
Male;
Microsatellite Repeats/*genetics;
Pedigree;
Receptors, GABA-A/*genetics
- From:Yonsei Medical Journal
2009;50(2):304-306
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/- 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.
