Application of indocyanine green coaxial fluorescence projective imaging for sentinel lymph node biopsy in acral malignant melanoma
10.3760/cma.j.cn114453-20221116-00360
- VernacularTitle:吲哚菁绿同轴荧光投影在肢端恶性黑色素瘤前哨淋巴结活检中的应用
- Author:
Qingshan CHENG
1
;
Liping ZHAO
;
Minggang WANG
;
Qiang WANG
;
Ru ZHANG
;
Tao LIN
;
Guangdi YIN
Author Information
1. 蚌埠医学院研究生院，蚌埠 233000
- Keywords:
Melanoma;
Sentinel lymph node biopsy;
Indocyanine green;
Coaxial fluorescent projection;
Methylene blue
- From:
Chinese Journal of Plastic Surgery
2023;39(4):401-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the tracer effect of indocyanine green (ICG) surgical coaxial fluorescence projective imaging system (CFPI) and methylene blue (MB) staining method in the sentinel lymph node biopsy (SLNB) of acral malignant melanoma.Methods:Data of patients with acral malignant melanoma requiring SLNB diagnosed in the First Affiliated Hospital of University of Science and Technology of China from March 2020 to October 2022 were retrospectively analyzed. Both ICG and MB were injected intraoperatively to trace the sentinel lymph node (SLN), and SLNB was performed according to fluorescent labeling. Numbers of SLN and metastatic SLN deteted by ICG, MB, ICG combined with MB during operation were recorded. Statistical analysis was performed using Graphpad Prism 6 software, and the detected number of SLN was expressed as Mean±SD, and paired t-test was performed. The detection rate of SLN was expressed by % and χ2 test was used. P<0.05 was considered statistically significant. Results:A total of 21 patients were included, and 62 SLNs were detected, among which 58 (93.5%) were detected by ICG, 41 (66.1%) by MB, and 62 (100.0%) by ICG combined with MB, respectively. The detection rate of ICG was significantly higher than that of MB, with statistical significance ( χ2=22.34, P=0.001). The detected numbers of SLNs by ICG, MB, ICG combined with MB were (2.76±0.23), (1.95±0.21) and (2.95±0.25) /per person, respectively. ICG was significantly more than MB, and the difference was statistically significant ( t=2.60, P=0.013). A total of 10 metastatic SLNs were detected, of which 10 were detected by ICG, 7 by MB, and 10 by ICG combined with MB. Conclusion:Compared with MB, ICG CFPI showed better performance in SLNB, and ICG combined with MB showed better performance than ICG alone.
