Research progress of botulinum toxin type A in the prevention and treatment of hypertrophic scar

VernacularTitle:A型肉毒毒素在增生性瘢痕防治中的研究进展
Author: Qingwen YANG ¹ ; Liang LI ; Yuanzheng CHEN
Author Information

1. 潍坊医学院，潍坊　261053
Keywords: Botulinum toxins; Botulinum toxin type A; Hypertrophic scar; Fibroblast
From: Chinese Journal of Plastic Surgery 2023;39(3):242-246
CountryChina
Language:Chinese
Abstract: Hypertrophic scar is the most common scar in clinic. Due to its high incidence, high rate of relapse and difficulty of complete removal, it has always been a big problem in burn and plastic surgery. In recent years, some scholars have found that botulinum toxin type A(BTX-A) can inhibit scar hyperplasia by reducing the tension around the wound, inhibiting the proliferation of fibroblasts, promoting their apoptosis, promoting the degradation of collagen fibers, reducing wound angiogenesis, reducing inflammation around the wound and other mechanisms. BTX-A has fewer adverse reactions and high safety. Additionally, its effect combined with triamcinolone acetonide and laser in treating scars is significant. Therefore, it has been widely used in the treatment of hypertrophic scars. In this paper, the research progress of BTX-A in the prevention and treatment of hypertrophic scar were reviewed in order to provide new ideas for the treatment of hypertrophic scar.