Regulatory role of macrophages in tissue regeneration
10.3760/cma.j.cn114453-20200420-00234
- VernacularTitle:巨噬细胞在组织再生中的调控作用
- Author:
Guo ZHANG
1
;
Zhenxing WANG
;
Jiaming SUN
Author Information
1. 华中科技大学同济医学院附属协和医院整形外科，武汉 430022
- Keywords:
Regenerative medicine;
Macrophages;
Immunomodulation;
Stem cell;
Stem cell niche
- From:
Chinese Journal of Plastic Surgery
2022;38(5):588-594
- CountryChina
- Language:Chinese
-
Abstract:
The regulatory effect of the immune system during tissue regeneration is gaining more and more attention, yet the underlying mechanisms remain unclear. Tissue regeneration requires a balanced immune response, especially the balanced polarization of macrophages (MΦ), to induce a conducive local microenvironment for tissue regeneration. In this review, the crucial effects of MΦ in tissue regeneration are summarized, including the elimination of cell debris, regulation of stem cell proliferation and differentiation, promotion of angiogenesi. In addition, the practical applications of MΦ in stem cell therapy and tissue engineering are introduced, in the hope of providing references for further exploration of the effect of immune cells on the stem cell niche, as well as the clinical translation of stem cell-based tissue engineering and regenerative medicine.
