Research progress in the pathogenesis of keloids
10.3760/cma.j.cn114453-20200217-00048
- VernacularTitle:瘢痕疙瘩发病机制研究进展
- Author:
Zhiguo SU
1
;
Jincai FAN
;
Liqiang LIU
;
Hu JIAO
;
Hongbo CHEN
;
Yihua CHEN
Author Information
1. 中国医学科学院北京协和医学院整形外科医院整形九科，北京 100144
- Keywords:
Keloid;
Pathogenesis;
Inflammation;
Glucose metabolism;
Signaling pathway
- From:
Chinese Journal of Plastic Surgery
2022;38(2):228-231
- CountryChina
- Language:Chinese
-
Abstract:
The etiology and pathogenesis of keloid are still not clear. It is believed that the formation of keloid is due to the joint action of many factors, during which process the external factor of fibroblast play an important role. Reprogramming of glucose metabolism in keloid fibroblasts is a new research direction. TGF-β 1 and its related TGF-β 1/Smad signalling pathway are considered to be the most closely related to the formation of keloid. This article reviews the research progress on extracellular factors, glucose metabolism and signaling pathways of keloids.
