Altered Cell Viability and Proliferation Activity of Peripheral Lymphocytes in Patients with Alzheimer's Disease.
- Author:
Se Chang YOON
1
;
Young Ah KWON
;
Hyeran KIM
;
Seonwoo KIM
;
Sangmee AHN JO
;
Doh Kwan KIM
Author Information
1. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
cell cycle;
Biomarker;
Cell death;
Peripheral lymphocytes
- MeSH:
Alzheimer Disease;
Architectural Accessibility;
Cell Cycle;
Cell Death;
Cell Survival;
Humans;
Lymphocytes;
Neurons
- From:Psychiatry Investigation
2010;7(1):68-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We evaluated cell viability and proliferation activity of peripheral lymphocytes as potential models of neuronal death in Alzheimer's disease (AD). METHODS: We analyzed the cell viability and proliferation activity of phytohemagglutinin (PHA)-activated lymphocytes from 68 AD patients and 33 normal controls. The cellular measures were made at baseline (0 hr), 24 hrs, 48 hrs, 72 hrs, and 96 hrs after PHA stimulation. RESULTS: Cell viability in the AD patients was significantly decreased at 72 hrs and 96 hrs, compared with the normal controls. The declining ramp of the proliferation activity from 48 hrs to 72 hrs after PHA stimulation was significantly related to cell viability at 72 hrs and at 96 hrs in the AD patients. CONCLUSION: Lymphocytes from patients with AD have altered viability and proliferation characteristics in culture following PHA stimulation. These findings suggest that lymphocytes may be used as a peripheral tissue model of cell cycle dysregulation in AD.
