Relationship between Allergic Rhinitis and Asthma in High School Students in Korea.
- Author:
Younghwa SONG
1
;
Ji Won KWON
;
Byoung Ju KIM
;
Bong Seong KIM
;
Ja Hyeung KIM
;
Hyo Bin KIM
;
So Yeon LEE
;
Jinho YU
;
Sun Mi YU
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, College of Medicine, Ulsan University, Korea. sjhong@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Brronchial hyperresponsiveness;
Allergic rhinitis;
Asthma;
One airway disease
- MeSH:
Adolescent;
Asthma;
Biomarkers;
Cross-Sectional Studies;
Eosinophilia;
Eosinophils;
Female;
Forced Expiratory Volume;
Humans;
Immunoglobulin E;
Korea;
Methacholine Chloride;
Prevalence;
Pyroglyphidae;
Surveys and Questionnaires;
Respiratory Function Tests;
Rhinitis;
Rhinitis, Allergic, Perennial;
Skin Tests
- From:Pediatric Allergy and Respiratory Disease
2010;20(1):30-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to determine whether allergic rhinitis (AR) without asthma is associated with bronchial hyperresponsiveness (BHR) and symptoms of asthma in Korean adolescents. METHODS: A questionnaire survey was conducted on 724 high school students (males 556; females, 168) from Seoul City. We also performed the lung function test, methacholine challenge test, skin prick test, and allergy-related blood biomarkers. This cross-sectional study was conducted in the subjects excluding current asthmatic patients. RESULTS: AR (+), BHR (+) patients tended to show a high prevalence of wheeze ever, a high diagnosis rate of asthma ever, low forced expiratory volume in one second (FEV(1)), low forced expiratory flow at the 25% and 75% of pulmonary volume (FEF(25-75%)) high total IgE and frequent sensitizaion to house dust mites compared with AR (-), BHR (-) patients. In atopy AR (+) group, wheeze ever and treatment of asthma during the last 12 months were significantly higher than atopy (-), AR (-) patients or atopy (+), AR (-) patients (P<0.05). In atopy (+), AR (+) patients, BHR and peripheral eosinophil percent were significantly higher than in other patients (P<0.05) and PC(20) was also significantly lower than in other patients (P<0.05). CONCLUSION: BHR in current AR was associated with FEV(1), FEF(25-75%), total IgE, and sensitization to house dust mites. Current AR was associated with symptoms of asthma, peripheral eosinophilia and BHR, regardless of atopy. This study showed a significant association between allergic rhinitis and asthma or BHR among Korean adolescents. This cross-sectional study supports the concept of 'one airway, one disease' between the AR and asthma.
