Progress in animal models of cell lines and infantile hemangioma
10.3760/cma.j.cn114453-20190218-00050
- VernacularTitle:细胞系与婴幼儿血管瘤动物模型研究进展
- Author:
Qingmei SHI
1
;
Shaorong LEI
Author Information
1. 柳州市人民医院乳腺甲状腺外科二病区 545000
- Keywords:
Hemangioma;
Cell line;
Animals;
Model
- From:
Chinese Journal of Plastic Surgery
2020;36(11):1292-1296
- CountryChina
- Language:Chinese
-
Abstract:
Infantile hemangioma is the most common benign tumors in infancy with predictable disease evolution and duration. At present, the basic understanding of the development, proliferation and regression of infantile hemangioma is not sufficient, an ideal lively human infantile hemangioma model which could provide a standard platform for observation of cellular, molecular basis of infantile hemangioma development and drug mechanism is urgently needed. Up to now, a model that completely mimics the biological behavior of infantile hemangiomas has not been successfully established, but the existing research progress has laid a solid foundation for the pathogenesis of hemangioma and clinical targeted therapy. In this paper, the research progress of cell line and animal model of infantile hemangioma and its clinical value in recent years were summarized, as well as the favorable factors that may be used in the construction of infant hemangioma model in the future, providing the latest reference for the selection of animal model of infantile hemangioma.
