RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 Gene Polymorphisms are not Associated with the Outcome of Hepatitis B Virus Infection: Results from a Large Scale Single Ethnic Population.
10.3346/jkms.2007.22.3.529
- Author:
Jae Youn CHEONG
1
;
Sung Won CHO
;
Jeong Young CHOI
;
Jung A LEE
;
Min Ho KIM
;
Jong Eun LEE
;
Ki Baik HAHM
;
Jin Hong KIM
Author Information
1. Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, Suwon, Korea. sung_woncho@hotmail.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Hepatitis B;
Single Nucleotide Polymorphism (SNP);
Chemokines;
Chemokine Receptors
- MeSH:
Chemokine CCL2/*genetics;
Chemokine CCL5/*genetics;
Disease Progression;
Genotype;
Hepatitis B/ethnology/*genetics/*therapy;
Hepatitis B virus/metabolism;
Humans;
Korea;
*Polymorphism, Genetic;
Receptors, CCR2;
Receptors, CCR5/*genetics;
Receptors, CXCR4/*genetics;
Receptors, Chemokine/*genetics;
Receptors, Interleukin-8A/*genetics;
Regression Analysis;
Treatment Outcome
- From:Journal of Korean Medical Science
2007;22(3):529-535
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recovery from hepatitis B virus (HBV) infection depends on the cellular immune responses. Chemokines and their receptors play significant roles in immune defense. This study was undertaken to investigate the association between HBV infection and single nucleotide polymorphisms (SNPs) of genes for the chemokines and their receptors. Between March 2002 and February 2004, a total of 957 single ethnic Korean patients were enrolled into two different groups; "HBV clearance group" (n=350), who have recovered from HBV infection, and "HBV persistence group" (n=607), who were repeatedly HBsAg-positive. The HBV persistence group was subdivided into "inactive carrier" and "HBV progression group (chronic hepatitis and cirrhosis)". We assessed polymorphisms in regulated and normal T-cell expressed and secreted (RANTES) at position -403, monocyte chemoattractant protein-1 (MCP-1) at position -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T and CXCR4 I138I using single primer extension assay. Genotype distributions of the "HBV clearance versus persistence group" and "inactive carrier versus HBV progression group" were compared. On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with RANTES -403, MCP-1 -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T, and CXCR4 I138I polymorphisms. In addition, no association of analyzed SNPs with HBV disease progression was found.
