The decellularized extracellular matrix in regenerative medicine

VernacularTitle:脱细胞基质材料与组织再生修复研究进展
Author: Yanling WEN ¹ ; Jun SHU ; Jinlong LI ; Zhijun WANG ; Yan HAN
Author Information

1. 宁夏崔大夫博士丽医疗美容门诊部，银川　750000
Keywords: Extracellular matrix; Decellularized extracellular matrix; Biological scaffolds; Regenerative medicine, tissue engineering
From: Chinese Journal of Plastic Surgery 2020;36(6):685-690
CountryChina
Language:Chinese
Abstract: Extracellular matrix material is obtained through decellularization of tissues or organs. It not only provides a 3D scaffold structure for regenerated tissue and cells, but also regulates the behavior of regenerated cells (including cell morphology, adhesion, proliferation, migration, differentiation and apoptosis). Induce stem cell proliferation and differentiation, and mediate cell signaling pathways and gene expression through mechanical sensing or receptor-mediated effects. Because of these good properties, extracellular matrix has been increasingly used in tissue regeneration in recent years. In this paper, the role and applications of acellular matrix materials in promoting tissue regeneration and reconstruction are analyzed and summarized.