Associated Factors with Parenteral Nutrition Associated Cholestasis in Neonates.
10.13029/jkaps.2015.21.1.1
- Author:
Kyoung Eun KIM
1
;
Hyon Hui LEE
;
Mi Lim CHUNG
;
Woon Won KIM
;
So Hyun NAM
Author Information
1. Department of Surgery, Inje University Haeundae Paik Hospital, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Newborn infant;
Parenteral nutrition;
Cholestasis
- MeSH:
Bilirubin;
Birth Weight;
Bronchopulmonary Dysplasia;
Cause of Death;
Cholestasis*;
Enteral Nutrition;
Enterocolitis, Necrotizing;
Gestational Age;
Humans;
Incidence;
Infant, Newborn*;
Liver;
Mortality;
Parenteral Nutrition*;
Parenteral Nutrition, Total;
Retrospective Studies;
Sepsis;
Survivors
- From:Journal of the Korean Association of Pediatric Surgeons
2015;21(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Long time total parenteral nutrition (TPN) can induce irreversible liver damage. In this study, we investigated the associated factors of parenteral nutrition associated cholestasis (PNAC) in neonates. METHODS: We retrospectively reviewed 227 neonates (male:female=110:117) those who had received TPN over 2 weeks from March 2010 to February 2014. PNAC was defined as direct bilirubin was higher than 2.0 mg/dL without any cause except TPN. RESULTS: Overall incidence was 28.6%. PNAC was frequently developed in younger gestational age with lower birth weight. Episodes of sepsis, underlying bronchopulmonary dysplasia, history of necrotizing enterocolitis, and experience of gastrointestinal surgery increase the incidence of PNAC. PNAC was directly associated the duration of TPN and long period to full enteral feeding, reaching 60 and 150 mL/kg/day. Overall mortality rate was 9.7%. It was higher in PNAC group despite PNAC was not the primary cause of death. All survivors were recovered from cholestasis with encourage of enteral nutrition. CONCLUSION: PNAC in neonate was associated with younger gestational ages and lower birth weights, duration of TPN, or who experienced sepsis, necrotizing enterocolitis, gastrointestinal surgery or bronchopulmonary dysplasia.
