Expression of Egr-1, Nab2 and Cav-1 and its relationship with scar hyperplasia
10.3760/cma.j.issn.1009-4598.2016.06.013
- VernacularTitle:Egr-1、Nab2和Cav-1的表达与瘢痕增生的相关性研究
- Author:
Zixiang CHEN
1
;
Guoqian YIN
;
Xinyuan PAN
;
Siding LU
;
Shenghua TANG
;
Qinxi WEI
;
Jiangying ZHU
Author Information
1. 中国医学科学院整形外科医院研究中心 100144
- Keywords:
Early growth response protein 1;
NGFI-A binding protein 2;
Caveolin 1;
Cicatrix
- From:
Chinese Journal of Plastic Surgery
2016;32(6):453-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of early growth response protein 1 (Egr-1),NGFI-A binding protein 2 (Nab2) and caveolin 1 (Cav-1) in normal skin,flat-cicatrix and hypertrophic scar,and explore its role in the formation of hypertrophic scar.Methods The expression of Egr-1,Nab2 and Cav-1 protein in 9 normal skin tissues,8 flat-cicatrix tissues and 9 hypertrophic scar tissues were examined with immunohistochemistry SP method and were analyzed statistically.Results The expression of Egr-1 in epidermal cells of hypertrophic scar was significantly higher than that in normal skin and flat scar tissue.The expression of Egr-1 increased in the course of scar proliferation.The distribution patterns of Nab2 were different from Egr-1.The expression of Egr-1 was increased,while expression of Nab2 was decreased.The expression of Cav-1 in normal skin and flat-cicatrix was significantly higher than that in hypertrophic scar.Conclusions The expression of Egr-1,Nab2 and Cav-1 is closely related to the formation of hypertrophic scar,and the up-regulated expression of Egr-1 and the deficient expression of Nab2 and Cav-1 may be the indicators of the progress of formation of hypertrophic scar.
