Expression of ABCC8 mRNA in gliomas and its application value as a prognostic indicator
10.3760/cma.j.cn112152-20200720-00668
- VernacularTitle:三磷酸腺苷结合盒式亚家族C成员8在脑胶质瘤组织中的表达及预后预测价值
- Author:
Kaijia ZHOU
1
;
Yanwei LIU
;
Zheng ZHAO
;
Ming ZHANG
;
Bowei LIU
Author Information
1. 福建医科大学附属肿瘤医院福建省肿瘤医院神经肿瘤外科，福州 350014
- Keywords:
Glioma;
Member 8 of ATP binding cassette subfamily C;
Molecular typing;
Prognosis
- From:
Chinese Journal of Oncology
2022;44(8):836-841
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mRNA expression of adenosine triphosphate binding cassette subfamily C member 8 (ABCC8) in gliomas and its application value as an index for predicting the prognosis of gliomas.Methods:The data of sex, age, histopathological type, WHO grade, isocitrate dehydrogenase (IDH) mutation, 1p/19q deletion, survival time and ABCC8 mRNA expression of 304 patients with gliomas (study group) in the Chinese glioma Genome Atlas (CGGA) database were collected. The prognostic factors of patients with gliomas were determined by univariate and multivariate Cox regression analysis. This result was verified by the data of 506 glioma patients in TCGA database and 271 glioma patients in REMBRANDT database.Results:The expression of ABCC8 mRNA in 304 cases of gliomas in the study group was 15.93±1.23. ABCC8 mRNA expression was correlated with age, histopathological type, WHO grade, IDH mutation status, 1p/19q deletion status and WHO molecular grade ( P<0.01). The median survival time of patients in ABCC8 mRNA high expression group was 85.60 months, which was significantly longer than 14.07 months in low expression group ( P<0.001). Univariate Cox regression analysis showed that age, histopathological type, WHO grade, IDH mutation status, 1p/19q deletion status, postoperative radiotherapy, postoperative chemotherapy and ABCC8 mRNA expression were related to the overall survival time of patients ( P<0.05). Multivariate Cox regression analysis showed that WHO grade ( HR=3.117, 95% CI: 1.970-4.930), 1p/19q deletion status ( HR=0.285, 95% CI: 0.155-0.526), postoperative chemotherapy ( HR=0.680, 95% CI: 0.488-0.948) and ABCC8 mRNA expression ( HR=0.690, 95% CI: 0.491-0.971) were independent factors for the overall survival of patients. In the TCGA dataset, the median survival time of patients with high ABCC8 mRNA expression group was 133.70 months, which was longer than 19.60 months of patients with low ABCC8 mRNA expression group ( P<0.001). In Rembrandt dataset, the median survival time of patients with high ABCC8 mRNA expression group was 37.93 months, which was longer than 15.83 months of patients with low expression group ( P<0.001). Conclusions:The expression level of ABCC8 mRNA in glioma is related to the degree of malignancy. The higher degree of malignancy, the lower the expression. The expression level of ABCC8 mRNA is an independent factor for the overall survival of patients with gliomas. The overall survival of patients with high ABCC8 mRNA expression is longer than that of patients with low ABCC8 mRNA expression.
