Altered p53 expression in Epstein Barr virus positive T cell lymphomas.
10.3346/jkms.1995.10.6.399
- Author:
Ju Hie LEE
1
;
Sang Sook LEE
;
June Sik PARK
;
Sun LEE
;
Moon Ho YANG
;
Tae Young YOON
Author Information
1. Department of Pathology, Kyung Hee University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
p53 immunohistochemistry;
EBV in site;
Head & neck lymphoma
- MeSH:
Follow-Up Studies;
Gene Expression;
Genes, p53;
Head and Neck Neoplasms/genetics/*metabolism/*virology;
Herpesviridae Infections/genetics/*metabolism;
*Herpesvirus 4, Human;
Human;
Lymphoma, T-Cell/genetics/*metabolism/*virology;
Prognosis;
Protein p53/*biosynthesis;
Support, Non-U.S. Gov't;
Tumor Virus Infections/genetics/*metabolism
- From:Journal of Korean Medical Science
1995;10(6):399-405
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recent studies have suggested a probable association between Epstein-Barr virus (EBV) and nasal/nasopharyngeal T cell lymphomas but the role of oncogenes or tumor suppressor genes is poorly understood. We have studied the frequency of p53 expression and its relation to the EBV infection in 33 Korean patients with head and neck (H&N) lymphomas. All cases (23 B cell & 10 T cell) were immunostained for p53 protein using the mAb D07 (Novocastra) and the avidin biotin peroxidase method. EBER in situ hybridization was performed using a fluorescein conjugated EBV oligonucleotide probe (Dako). Among 33 lymphomas, 16 cases stained positively for p53 protein. P53 expression was frequent both in higher grade lymphomas and in advanced stage. Nine cases were EBER positive, EBER was more commonly found in T cell lymphomas than in B cell lymphomas (70% vs 8.7%). EBER positive lymphomas showed a higher frequency of p53 positivity than EBER negative lymphomas (78% vs 38%), although the difference was not statistically significant (p = 0.095). These findings indicate altered expression of p53 protein occurs in H&N lymphomas, especially in late event lymphoma progression and appears to play a role in the development of EBER positive T cell lymphomas.
