Diagnosis, treatment and prognosis evaluation of pancreatic cancer by microRNA
10.3760/cma.j.cn112152-20190313-00152
- VernacularTitle:微小RNA与胰腺癌的诊断治疗及预后评估
- Author:
Hu REN
1
;
Chengfeng WANG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室 胰胃外科 100021
- Keywords:
Pancreatic neoplasms;
MicroRNA;
Diagnosis;
Treatment;
Prognosis
- From:
Chinese Journal of Oncology
2020;42(11):903-906
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer, with the characteristics of insidious onset, easy metastasis, chemotherapy resistance and poor prognosis, is a common malignant tumor of the digestive system. Early diagnosis and treatment of pancreatic cancer is one of the major problems in modern medicine, and there is an urgent need to find new diagnostic, prognostic biomarkers and therapeutic targets. MicroRNA (miRNA) is a small non-coding RNA which can regulate the expression of various genes. miRNAs have wide abnormal expressions in pancreatic cancer, and are closely related to the occurrence and development of pancreatic cancer. Thereby, miRNAs have the potential to become new diagnostic, prognostic and predictive biomarkers and therapeutic targets of pancreatic cancer. Many studies have initially shown that miRNAs have the application value in the diagnosis, treatment and prognosis evaluation of pancreatic cancer, but there are still some difficulties in the practical application and promotion. The mechanisms of miRNAs in pancreatic cancer remain to be further studied.
