Susceptibility genes and risk prediction model of cardiovascular toxicity related to antineoplastic therapy in tumor patients
10.3760/cma.j.cn112152-20190801-00489
- VernacularTitle:肿瘤患者抗肿瘤治疗相关心血管毒性的易感基因及风险预测模型
- Author:
Binliang LIU
1
;
Fei MA
;
Yixin ZENG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院内科 100021
- Keywords:
Breast neoplasms;
Antineoplastic therapy associated cardiovascular toxicity;
Genetic susceptibility to cardiovascular toxicity;
Risk prediction model
- From:
Chinese Journal of Oncology
2020;42(10):838-842
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular toxicity of cancer patients in antineoplastic therapy is gradually paid widespread attention. Although many high-risk factors of cardiovascular toxicity associated with chemotherapy, targeted therapy or immunotherapy have been identified, it is still difficult to establish accurate risk prediction model. Traditional risk prediction model cannot adequately explain the differences in cardiovascular toxicity susceptibility among patients, makes it difficult to accurately screen high-risk groups, early diagnose and prevent cardiovascular toxicity. Finding susceptible genes of cardiovascular toxicity associated with antineoplastic therapy and incorporating single-nucleotide polymorphisms into risk prediction model can significantly improve the identification of high-risk population of cardiovascular toxicity.
