Efficacy analysis of the radiotherapy and chemotherapy in patients with stage Ⅳ esophageal squamous carcinoma: a multicenter retrospective study of Jing-Jin-Ji Esophageal and Esophagogastric Cancer Radiotherapy Oncology Group (3JECROG R-01F)
- VernacularTitle:Ⅳ期食管鳞癌放化疗疗效分析：泛京津冀食管肿瘤多中心协作组多中心回顾性研究(3JECROG R-01F)
- Author:
Miaomiao HU
1
;
Qianqian YUAN
;
Xusheng ZHANG
;
Sen YANG
;
Xin WANG
;
Lan WANG
;
Junqiang CHEN
;
Wencheng ZHANG
;
Xiaomin WANG
;
Xiaolin GE
;
Wenbin SHEN
;
Yonggang XU
;
Chongli HAO
;
Zhiguo ZHOU
;
Shuai QIE
;
Na LU
;
Qingsong PANG
;
Yidian ZHAO
;
Xinchen SUN
;
Gaofeng LI
;
Ling LI
;
Xueying QIAO
;
Miaoling LIU
;
Yadi WANG
;
Chen LI
;
Shuchai ZHU
;
Chun HAN
;
Kaixian ZHANG
;
Zefen XIAO
Author Information
- Keywords: Esophageal squamous cell carcinoma; Radiotherapy; Chemotherapy; Prognosis
- From: Chinese Journal of Oncology 2020;42(8):676-681
- CountryChina
- Language:Chinese
- Abstract: Objective:To evaluate the survival and prognostic factors of radiotherapy in patient with Ⅳ stage esophageal squamous carcinoma treated with radiation or chemoradiation.Methods:The medical records of 608 patients with stage Ⅳ esophageal squamous cell carcinoma who met the inclusion criteria in 10 medical centers in China from 2002 to 2016 were retrospectively analyzed. The overall survival and prognostic factors of all patients at 1, 3 and 5 years were analyzed.Results:The 1-, 3-, 5- year overall survival (OS) rates was 66.7%, 29.5% and 24.3% in stage ⅣA patients, and 58.8%, 29.0% and 23.5% in stage ⅣB patients. There was no statistical difference between the two groups ( P=0.255). Univariate analysis demonstrated that the length of lesion, treatment plan, planned tumor target volume (PGTV) dose, subsequent chemotherapy, and degrees of anemia, radiation esophagitis, radiation pneumonia were related to the prognoses of patients with Ⅳ stage esophageal carcinomas after radiotherapy and chemotherapy ( P<0.05). Multivariate analysis demonstrated that PGTV dose ( OR=0.693, P=0.004), radiation esophagitis ( OR=0.867, P=0.038), and radiation pneumonia ( OR=1.181, P=0.004) were independent prognostic factors for OS. Conclusions:For patients with stage Ⅳ esophageal squamous cell carcinoma, chemoradiotherapy followed by sequential chemotherapy is recommended, which can extend the total survival and improve the prognosis of the patients. PGTV dose more than 60 Gy has better efficacy.
