The metabolism of blood glucose and lipid in breast cancer patients after the first chemotherapy
10.3760/cma.j.cn112152-20200521-00471
- VernacularTitle:乳腺癌首次足疗程化疗后血糖血脂代谢状况的临床分析
- Author:
Xiaoying SUN
1
;
Fei MA
;
Pengfei TIAN
;
Xiaoshuang LI
;
Aihua ZHU
;
Jinjing WANG
;
Binliang LIU
Author Information
1. 北京市朝阳区桓兴肿瘤医院肿瘤内科 100021
- Keywords:
Breast neoplasms;
Chemotherapy;
Blood glucose;
Lipid
- From:
Chinese Journal of Oncology
2020;42(7):580-585
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the metabolism of blood glucose and lipid in breast cancer patients after the first chemotherapy.Methods:Breast cancer patients who received chemotherapy for the first time from December 2016 to January 2020 were collected in our hospital, and their blood glucose and lipid levels were monitored. Patients were grouped according to different treatment plans. Non-parametric rank sum test was used for statistical analysis on SPSS software.Results:There were 1 356 female breast cancer patients were enrolled, blood glucose and lipid levels were compared before and after chemotherapy. Our results showed that baseline medium blood glucose was 5.2 mmol/L, lower than 5.3 mmol/L after chemotherapy ( P<0.05). The baseline triglyceride (TG) was 1.2 mmol/L, lower than 1.6 mmol/L after chemotherapy ( P<0.05). The baseline small dense low-density lipoprotein (sdLDL) was 0.7 mmol/L, lower than 0.8 mmol/L after chemotherapy ( P<0.05). The baseline high density lipoprotein (HDL) was 1.3 mmol/L, higher than 1.2 mmol/L after chemotherapy ( P<0.05). Patients′ menstrual status and body mass index were related with blood glucose, TG, LDL and sdLDL (all P< 0.05). Conclusions:Abnormal metabolism of blood glucose and lipid are observed in breast cancer patients after the first chemotherapy. More awareness of cardiovascular disease in breast cancer patients might ensure their overall clinical benefits.
