Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder.
- Author:
Hoon JANG
1
;
Wun Jae KIM
;
Hyung Lae LEE
Author Information
1. Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Cyclooxygenase-2;
Bladder cancer;
Immunohistochemistry;
Staining
- MeSH:
Breast;
Carcinogenesis;
Carcinoma, Transitional Cell*;
Case-Control Studies;
Cyclooxygenase 2*;
Cystectomy;
Epithelial Cells;
Gastrointestinal Tract;
Head;
Humans*;
Immunohistochemistry;
Neck;
Paraffin;
Prostatic Hyperplasia;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
2004;45(6):530-534
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recent studies have supported the important role of cyclooxygenase-2 (COX-2) in various cancers derived from epithelial cell, such as the gastrointestinal tract, breast, head, and neck. In this case-control study, the clinical significance of COX-2 expression was investigated in patients with transitional cell carcinoma (TCC) of the urinary bladder. MATERIALS AND METHODS: Tumor samples were obtained from 43 bladders of TCC patients undergoing either transurethral resection (TUR) or radical cystectomy. Normal bladder tissues were also acquired from 50 age- and sex-matched patients without bladder cancer, mainly in benign prostatic hyperplasia. Paraffin sections were assessed with immunohistochemistry using the anti-human COX-2 monoclonal antibody. COX-2 expression was graded on a scale of 0-3+ according to the intensity and rate of immunohistochemical staining. RESULTS: COX-2 was expressed in 42 of 43 (97.7%) in human TCCs of the urinary bladder but not in all normal bladder tissues (p<0.001). COX-2 expression was significantly higher in invasive tumors than in superficial TCCs (p=0.038). Additionally, COX-2 expression had a significant correlation with the tumor stage (p=0.016), but not with the tumor grade (p=0.169). CONCLUSIONS: This study showed that COX-2 was expressed in human TCCs of the urinary bladder, and its expression was highly correlated to the tumor stage. These results support the possibility that COX-2 might play an important role in tumorigenesis and invasiveness of human TCCs of the urinary bladder.
