Expression of NUSAP1 and its relationship with prognosis in non?small cell lung cancer
10.3760／cma.j.issn.0253?3766.2019.07.007
- VernacularTitle:核仁纺锤体相关蛋白1在非小细胞肺癌中的表达及其与患者预后的关系
- Author:
Zhe YU
1
;
Xiaomin LI
;
Mei HUAI
;
Shanshan CAO
;
Hongyong HAN
;
Haitao LIU
Author Information
1. 华北石油管理局总医院心胸科
- Keywords:
Non?small cell lung cancer;
Nucleolar and spindle?associated protein 1;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(7):522-526
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of nucleolar and spindle?associated protein 1 (NUSAP1) in non?small cell lung cancer ( NSCLC) and analyze its relationship with the prognosis of NSCLC patients. Methods Real?time fluorescent quantitative PCR and immunohistochemical staining were performed to determine the expression of NUSAP1 in NSCLC tissues and adjacent tissues collected from hospital. The relationship between NUSAP1 expression and prognosis of NSCLC patients was analyzed by online database. Results The expression level of NUSAP1 mRNA in tumor tissues was significantly higher than that of adjacent tissues (P＜0.05). The high expression rate of NUSAP1 protein in NSCLC tissues was 58.0%( 29／50), significantly higher than 22.0%( 11／50) of adjacent tissues ( P＜0.05). The high expression of NUSAP1 protein in NSCLC tissues was closely correlated with tumor size, lymph node metastasis and TNM stage ( P＜0.05), but was not related to age and gender. The data showed that the expression level of NUSAP1 mRNA was inversely associated with the overall survival ( OS) of NSCLC patients ( P＜0.001). The expression of NUSAP1 mRNA was significantly correlated with the pathological grade, clinical stage, gender, chemotherapy, smoking history, and histological type of NSCLC patients (P＜0.05). Conclusions The expression of NUSAP1 is up?regulated in NSCLC, which is correlated with the growth and development of NSCLC and prognosis of the patients. These results indicate that NUSAP1 can be used as a potential prognostic marker for NSCLC.
