Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer
10.3760/cma.j.issn.0253-3766.2016.09.010
- VernacularTitle:孕激素受体缺失对可手术雌激素受体阳性乳腺癌患者预后的影响
- Author:
Ruimin MA
1
;
Chuanzhi CHEN
;
Chuanqi LIN
;
Wei ZHANG
;
Guilong GUO
Author Information
1. 325000,温州医科大学附属第二医院育英儿童医院乳腺外科
- Keywords:
Breast neoplasm;
Progesterone receptor;
Estrogen receptor;
Prognosis
- From:
Chinese Journal of Oncology
2016;38(9):687-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of lack of progesterone receptor ( PR) expression on the prognosis of patients with operable ER ( estrogen receptor)?positive invasive breast cancer. Methods We retrospectively analyzed the clinicopathological features, treatment and survival data of 318 women with ER+/PR+ and ER+/PR? invasive breast cancer. Results Among the 318 patients, there were 219 PR?positive and 99 PR?negative cases. The 5?year overall survival ( OS ) rate was 92. 5%, and the 5?year disease?free survival ( DFS) rate was 87. 2% in the 318 ER?positive patients. Among them, the 5?year OS rates were significantly different between the PR?positive group (94.6%) and PR?negative group (87.8%, P=0.020), and the 5?year DFS rates were also significantly different from each other (89.8% and 81.6%, respectively, P=0.019).Univariate analysis showed that PR status, tumor size, T stage, axillary lymph node metastasis, and clinical stage were prognostic factors for OS ( P<0.05 for all) . Multivariate analysis showed that lack of PR expression, T stage ≥2, and positive axillary lymph node metastasis were independent risk factors for poor DFS and OS in ER?positive breast cancer patients ( P<0. 05 for all ) . Subgroup analysis showed that lack of PR expression was not significant in predicting poor DFS or OS when patients were in stageⅠ or with a small tumor (≤2 cm) (P>0.05 for all), and also showed that premenopausal women with PR?negative disease had poorer DFS and OS than PR?positive patients ( P<0.05 for both) . Conclusions Lack of PR expression is an independent risk factor for poor prognosis in patients with operable ER?positive invasive breast cancer, especially in patients with a large tumor (>2 cm) , advanced clinical stage ( StageⅡ or Ⅲ) or in premenopausal status.
