HER-2 expression and clinical significance in esophagogastric junction adenocarcinoma (Siewert typeⅡ)
10.3760/cma.j.issn.0253-3766.2016.09.006
- VernacularTitle:人表皮生长因子受体2在Siewert Ⅱ型食管胃交界腺癌中的表达及其临床意义
- Author:
Zhilin LUO
1
;
Maoyong FU
;
Dong TIAN
;
Guidong SHI
Author Information
1. 川北医学院附属医院胸心外科
- Keywords:
Human epidermal growth factor receptor-2;
Esophagogastric junction adenocarcinoma;
Siewert type Ⅱ;
Clinicopathological features;
Prognosis
- From:
Chinese Journal of Oncology
2016;38(9):667-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the human epidermal growth factor receptor?2 ( HER?2 ) expression in esophagogastirc junction adenocarcinoma ( Siewert type Ⅱ) and its clinical significance. Methods A total of 180 patients with esophagogastric junction adenocarcinoma ( Siewert type Ⅱ) were included in this study. The HER?2 expression was detected by immunohistochemistry ( IHC ) , and fluorescence in situ hybridization ( FISH) analysis was performed to assess the HER?2 gene amplification in the IHC?positive and IHC?weak positive cases. Results HER?2 overexpression ( 3+) , weak positive ( 2+) and negative (1+/0) was 11.7%(21/180), 8.9%(16/180), and 79.4%(143/180), respectively. The FISH analysis showed HER?2 gene amplification in 95.2%(20/21) of HER?2(3+) cases and 18.8% (3/16) of HER?2( 2+) cases. The concordance rate between IHC and FISH was 95. 2%. Overexpression of HER?2 (3+) was associated with the tumor differentiation (P<0.05), and irrelevant to age, sex, pT stage, pN stage, pM stage and pTNM stage ( P>0.05) . The median overall survival time ( OS) was 13 months in HER?2( 3+) patients, significantly shorter than the 21 months in HER?2 ( 2+) and HER?2 (+/-) cases ( P<0.01) . Conclusions Approximately 11. 7% of the patients with esophagogastric junction adenocarcinoma ( Siewert type Ⅱ) are HER?2?positive on IHC. HER?2 overexpression is associated with the tumor differentiation. IHC can be used as a screening test for the positive expression of HER?2 in the esophagogastirc junction adenocarcinoma ( Siewert typeⅡ) . However, FISH detection can be used as a more reliable detection method.
