Relationship between microsatellite instability and hepatocyte growth factor expression and their prognostic significance in colorectal cancer
10.3760/cma.j.issn.0253-3766.2016.04.008
- VernacularTitle:结直肠癌中微卫星不稳定性与肝细胞生长因子表达的关系及预后因素
- Author:
Guang YANG
1
;
Huixia ZHENG
;
Lina WU
;
Huili WAN
;
Ning LI
;
Gaochao YANG
;
Jianfang LIANG
Author Information
1. 山西医科大学 山西省肿瘤医院普通外科
- Keywords:
Colorectal neoplasms;
Hepatocyte growth factor;
Microsatellite instability;
Immunohistochemistry;
Prognosis
- From:
Chinese Journal of Oncology
2016;38(4):283-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hepatocyte growth factor ( HGF ) and its relationship with microsatellite instability ( MSI) and their influence on survival in patients with colorectal cancer. Methods Immunohistochemistry ( IHC) was used to detect the expression of HGF and MSI in 98 specimens of colorectal cancer. Tumors lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as MSI, and the rest were considered as microsatellite stable ( MSS) . The associations between expression and clinicopathological factors were assessed using Chi?square tests. Kaplan?Meier curves, log?rank test, and Cox regression were used to analyze the association between biomarker expressions and overall survival. Results The incidence rate of MSI in 98 colorectal specimens was 32. 7%, and was statistically significantly correlated with the location of tumor and differentiation degree ( P<0.05) . The HGF?expression rate was 71.4%. The patients with an MSI tumor had a significantly higher HGF expression, compared with the patients with an MSS tumor (P=0.048). The 5?year survival rate of MSI group and MSS group were 39.8% and 58.7%, respectively (P=0.009). The 5?year survival rate of HGF?positive group and HGF?negative group were 46.2% and 67.9% ( P=0.035) . The multivariate analysis showed that lymphocytic infiltration, TMN stage, MSI and HGF are independent prognostic factors in colorectal cancer ( P<0. 05 for all ) . Conclusions HGF is highly expressed in colorectal cancer patients with microsatellite instability. Both microsatellite instability and HGF are independent factors affecting the prognosis in patient with colorectal cancer.
