Efficacy evaluati on and exploration of TACE combined with CT-guided precision microwave ablation treatmen tf or pri mary liver cancer
10.3760/cma.j.issn.0253-3766.2016.02.012
- VernacularTitle:肝动脉导管化疗栓塞联合 CT 引导精准微波消融治疗原发性肝癌的疗效及影响因素
- Author:
Peng ZHAO
1
;
Jiasheng ZHENG
;
Honghai ZHANG
;
Chunwnag YUAN
;
Chang Shi CUI
;
Ning DU
;
Liying ZHAO
Author Information
1. 100069,首都医科大学附属北京佑安医院肿瘤微创介入中心
- Keywords:
Liver neoplasms;
Catheter ablation;
Transcatheter arterial chemoembolization;
Treatment outcome;
Prognosis
- From:
Chinese Journal of Oncology
2016;38(2):138-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical therapeutic efficacy of transcatheter arterial chemoembolization combined with CT-guided percutaneous precision microwave ablation for the treatment of primary liver cancer and its influencing factors.Methods A total of 126 patients with primary liver cancer were treated by transcatheter arterial chemoembolization combined with CT-guided percutaneous precision microwave ablation from Mar 2010 to Oct 2014 in our center.The treatment effect, postoperative complications and recurrence rates were observed, and the factors related to recurrence and survival time were analyzed.Results All 126 primary liver cancer patients with 201 tumors were ablated for 177 times, and 113 cases with 185 tumors were completed ablated, the complete ablation rate was 92.0%.In all patients, 4 cases had serious complications, the incidence rate was 3.2%.37 cases had recurrence, with a recurrence rate of 29.4%.All patients were followed up for 10 to 65 months, 17 patients died, and the 1-, 2-, and 3-year cumulative survival rates were 95.2%, 88.1%, and 84.1%, respectively, and the 1-, 2-, and 3-year progression-free-survival rates were 81.5%, 62.7% and 49.2%, respectively .Univariate analysis showed that preoperative AFP level, Child-Pugh score, BCLC stage and the largest tumor size were associated with the survival of patients who received TACE combined with CT-guided precision MWA, and the preoperative AFP level, internal medicine therapy, tumor number and the largest tumor size were associated with the progression-free-survival after the treatment (P<0.05).Multivariate analysis showed that Child-Pugh score and BCLC stage were independent factors affecting the survival of patients with primary liver cancer patients treated with TACE combined with CT guided percutaneous MWA, and the tumor number and the maximum tumor size were independent factors affecting the progression-free-survival of the patients (P <0.05).Conclusion TACE combined with CT-guided percutaneous precision microwave ablation therapy for primary liver cancer has reliable safety and efficacy.
