Hyalinizing Spindle Cell Tumor with Giant Rosettes with Pulmonary Metastasis After a Long Hiatus: A Case Report.
10.3346/jkms.2004.19.4.619
- Author:
Eundeok CHANG
1
;
Anhi LEE
;
Eunjung LEE
;
Okran SHIN
;
Changsuk KANG
;
Joon Mee KIM
;
Young Chae CHU
Author Information
1. Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea. anhilee@olmh.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Hyalinizing Tumor;
Rosettes Formation;
Sarcoma;
Lung;
Metastasis
- MeSH:
Adult;
Female;
Humans;
Hyalin/metabolism;
Korea;
Lung Neoplasms/diagnosis/*pathology/*secondary/ultrastructure;
*Neoplasm Metastasis;
Pleural Effusion/pathology;
Sarcoma/diagnosis/*pathology/ultrastructure;
Thigh/pathology;
Time Factors
- From:Journal of Korean Medical Science
2004;19(4):619-623
- CountryRepublic of Korea
- Language:English
-
Abstract:
"Hyalinizing spindle cell tumor with giant rosettes" (HSCTGR) is a recently described tumor, which is regarded as an unusual variant of low-grade fibromyxoid sarcoma. Proof of a metastatic potential was lacking. The patient in the report was a 35-yr-old woman who showed multiple bilateral pulmonary nodules with massive pleural effusion in the right side. She had a history of a mass excision in the right thigh 11 yrs ago at another hospital, which was reported as a "leiomyoma". Two years before this presentation, the patient received a routine chest radiograph which demonstrated bilateral multiple pulmonary nodules. A lobectomy of the left upper lung was performed. The histological findings revealed a well-circumscribed nodule that was characterized by a spindle-shaped fibrous to hyalinized stroma with criss-crossing short fascicles and giant collagen rosettes surrounded by a rim of spindle-shaped cells. Electron microscopy confirmed the fibroblastic nature of the tumor. This case, in addition to at least two other cases reported in the literature, demonstrates that the HSCTGR is a malignant neoplasm with the capacity to metastasize after a long hiatus.
