Efficacy of crizotinib for 28 cases of advanced ALK-positive non-small cell lung cancer
10.3760/cma.j.issn.0253-3766.2015.10.015
- VernacularTitle:克唑替尼治疗28例间变性淋巴瘤激酶阳性晚期非小细胞肺癌疗效分析
- Author:
Wenxian WANG
1
;
Zhengbo SONG
;
Xinmin YU
;
Guangyuan LOU
;
Cuiping GU
;
Xun SHI
;
Jun ZHAO
;
Yiping ZHANG
Author Information
1. 浙江省肿瘤医院胸部肿瘤内科 浙江省胸部肿瘤重点实验室
- Keywords:
Carcinoma,non-small-cell lung;
Treatment outcome;
Anaplastic lymphoma kinase;
Crizotinib
- From:
Chinese Journal of Oncology
2015;(10):784-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to evaluate the efficacy and safety of crizotinib for advanced ALK?positive non?small cell lung cancer ( NSCLC) patients. Methods Twenty?eight patients with advanced ALK?positive NSCLC were given orally crizotinib 250 mg b. i. d., and were followed up to evaluate the therapeutic efficacy and safety. Results Among the 28 patients, the objective response rate ( ORR) was 71.4%(20/28) and disease control rate (DCR) was 92.9% (26/28). Three patients achieved complete response. Seventeen patients had partial response. The most common drug?related adverse events were mild flickering vision and gastrointestinal reaction. Eleven patients experienced flickering vision. Nine patients had nausea and vomiting. Eight patients had diarrhea. They were all reversible and of grade Ⅰ or Ⅱ. Only one patient had grade Ⅲ myelosuppression. Among the 28 patients, 16 cases were disease?free and 12 cases had progressive disease, with a progression?free survival of 8.2 months. Conclusions Crizotinib is effective and tolerable in the treatment of advanced ALK?positive NSLCC. However, its long?term treatment efficacy requires to be further studied.
