Clinicopatho logical features and prognostic analysiso f pait ents with signet ring cle l gastir c carcinoma
10.3760/cma.j.issn.0253-3766.2015.05.011
- VernacularTitle:胃印戒细胞癌的临床病理特点和预后分析
- Author:
Jingli CUI
1
;
Han LIANG
;
Jingyu DENG
;
Xuewei DING
;
Xiaona WANG
;
Li ZHANG
;
Ng Yuexia LIANG
;
Nan Iagn J
Author Information
1. 300060天津医科大学肿瘤医院胃部肿瘤科,国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室
- Keywords:
Stomach neoplasms;
Carcinoma,signet ring cell;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of Oncology
2015;(5):367-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinicopathological features of signet ring cell gastric carcinoma ( SRCC) with those of non-signet ring cell cancers and explore the prognostic factors of signet ring cell gastric carcinoma.Methods We retrospectively reviewed the medical records of 1447 gastric cancer patients, including gastric signet ring cell and non-signet ring cell cancers.Their clinicopathological characteristics and overall survival data were analyzed.Results The differences in the age, sex, tumor location, depth of invasion, lymph node metastasis, distant metastasis, TNM classification and surgical type were significant between gastric signet ring cell and non-signet ring cell gastric carcinomas.The 5-year survival rate of the patients with gastric signet ring cell carcinoma was 29.6%, while that of the non-signet ring cell cancers was 42.9%(P<0.05).The 5-year survival rate for each stage of gastric signet ring cell carcinoma and non-signet ring cell cancers was 71.0%and 79.3%for stageⅠ, 45.6%and 58.3%for stageⅡ, 16.9%and 29.2%for stageⅢ,and 6.0%and 11.9%for stageⅣcases, respectively, with a significant difference only between stages Ⅲ and Ⅳ cancers ( P<0.05 ) .Multivariate analysis showed that tumor diameter, T stage and N stage were independent prognostic factors for signet ring cell gastric carcinoma. Conclusions The signet ring cell gastric carcinoma has unique clinicopathological features compared with non-signet ring cell carcinoma.Early detection and treatment can improve the prognosis for patients with gastric signet ring cell carcinoma.
