Correlation factors of lymph nod e metastasis in patients with clinical stage T1a non-small cell lung cancer
10.3760/cma.j.issn.0253-3766.2015.04.012
- VernacularTitle:临床 T1a 期非小细胞肺癌淋巴结转移相关因素分析
- Author:
Ruochuan ZANG
1
;
Shugeng GAO
;
Jei HE
;
Yousheng MAO
;
Qi XUE
;
Dali WANG
;
Juwei MU
;
Jun ZHAO
;
Yonggang WANG
;
Ngyang Xia LIU
;
Fengwei TAN
;
Gefei ZHAO
;
Qian ZHANG
;
Moyan ZHANG
;
Peng SONG
Author Information
1. 100021,北京协和医学院 中国医学科学院肿瘤医院胸外科
- Keywords:
Carcinoma,non-small-cell Lung;
Neoplasm staging;
Lymphatic metastasis
- From:
Chinese Journal of Oncology
2015;(4):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the lymph node metastasis and clinicopathological features in patients with clinical stage T1a non-small cell lung cancer ( NSCLC ) . Methods Clinicopathological data of a total of 418 patients who underwent lobectomy and systematic lymph node dissection were retrospectively analyzed.Logistic regression was used to analyze the relationship between lymph node metastasis and clinicopathological features.Resulst Lymph node metastasis was observed in 25 patients.There were 122 patients who were diagnosed as ground glass opacity with no lymph node metastasis.399 patients had subcarinal dissection, among them 7 patients were found to have lymph node metastasis.Univariate analysis showed that gender, smoking history, diameter of lymph node, ground glass opacity ( GGO ) , differentiation of the tumor and tumor site were the factors affecting lymph node metastasis ( all P<0.05) .Logistic regression analysis showed that diameter of lymph node, differentiation of the tumor and the site of lesion were independent risk factors for lymph node metastasis of NSCLC. Conclusions Tumor in the left lung, poor differentiation, and diameter of lymph nodes ≥1 cm on the preoperative CT image are independent risk factors for lymph node metastasis of NSCLC, hence we should pay attention before surgery and systematic lymph node dissection should be done.For patients with poor differentiation and lymph nodes≥1 cm, subcarinal lymph nodes dissection is recommended for the sake of higher possibility of lymph node metastasis.For patients with ground glass opacity≤2 cm, the lymph node metastasis is extremely rare, therefore, selective lymph node dissection is reconmmended.
