99Tcm-octreotide somatostatin receptor imaging in the diagnosis of lung cancer
10.3321/j.issn:0253-3766.2008.01.016
- VernacularTitle:99Tcm-奥曲肽显像在肺癌诊断中的应用
- Author:
Xiu-Juan WANG
1
;
Yuan REN
;
Xian-Feng LI
;
Si-Jin LI
;
Jian-Zhong LIU
Author Information
1. 山西省肿瘤医院
- Keywords:
Lung cancer;
Somatostatin receptor;
Octreotide;
Nuclide imaging
- From:
Chinese Journal of Oncology
2008;30(1):63-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of 99Tcm-octrotide somatostatin receptor imaging in the diagnosis of lung cancer. Methods Thirty consecutive patients with pulmonary neoplasms were studied. All lesions detected by scintigraphy were confirmed by histopathology and/or by other imaging modalities. Tumor to non-tumor tissue ratios (T/N) was calculated for semiquantitative analysis. The statistical analysis was carried out using Student t test. Results The sensitivity, specificity and accuracy in differentiating malignant from benign lesion was 95.7%, 71.4% and 90.0%, respectively. Positive image finding was obtained in 24 of 30 patients, and 2 of those was actually false positive on 99Tcm-octrotide imaging. Six patients had negative 99Tcm-octrotide imaging, and one of these was false negative. Forty-six lesions were detected by nuclear imaging, and 3 of these 46 lesions had not been revealed by CT or ultrasound examination. T/N ratio was 2.78±1.07 for SCLC and 1.75±0.31 for NSCLC, respectively(t=3.82,P< 0.05). Conclusion 99Tcm-octreotide somatostatin receptor image can display the distribution of somatostatin receptor in lung cancer. The octreotide uptake rate in small cell lung cancer is significantly higher than in non-small lung cancer, therefore, 99Tca-octreotide image may be more helpful in detecting small cell lung cancer. It can be used as a supplementary diagnostic method to other conventional method.
