The role of SYT-SSX fusion genes in the development of synovial sarcoma and their prognostic value
10.3321/j.issn:0253-3766.2008.01.010
- VernacularTitle:SYT-SSX融合基因及其亚型在滑膜肉瘤发生发展中的作用及预后意义
- Author:
Bao-Cun SUN
1
;
Yan SUN
;
Jian WANG
;
Xiu-Lan ZHAO
;
Jing CHEN
;
Xiao-Qing LI
;
Yu-Mei FENG
;
Zhi-Wei FANG
;
Xi-Shan HAO
Author Information
1. 天津医科大学肿瘤医院
- Keywords:
Synovial sarcoma;
SYT-SSX;
SYT-SSX1;
SYT-SSX2;
Epithelial differentiation;
Prognosis
- From:
Chinese Journal of Oncology
2008;30(1):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and role of SYT-SSX fusion genes in the carcinogesis of synovial sarcoma, and to evaluate their prognostic value as well. Methods RNA was extracted from 152 selected synovial sarcoma tissue blocks embedded in paraffin. The expression of SYT-SSX fusion genes was deteeted with RT-PCR method. The correlation of SYT-SSXI and SYT-SSX2 expression with clinieopathologic parameters and survival rate were analyzed. Results SYT-SSX was positively detected in 145 specimens (95.4%), 34.5% (50/145) of these in SYT-SSX1 and 62.8% (91/145) in SYT-SSX2, respectively. However, 2.8% (4/145) were negative for SYT-SSX1 and SYT-SSX2. The positive rate of biphasic type, CK-positive and EMA-positive in SYT-SSXl-synovial sarcoma were significantly higher than that in SYT-SSX2-synovial sarcoma (P<0.05 ). The multivariate analysis showed that the prognosis of patients with tumor diameter ≥ 5cm ( RR=2.325, P=0.027), containing poor differentiation areas (RR=2.122, P=0.048)), with metastasis ( RR=2.205, P=0.032) and expressing SYT-SSX1 (RR=2.775, P=0.008) was poor. Conclusion Most of Chinese synovial sarcomas have expression of SYT-SSX2 protein. SYT-SSX type may be considered as an important prognostic factor for synovial sareoma patient. The expression of SYT-SSX1 may suggest a poor prognosis. SYT-SSX1 and SYT- SSX2 show different ability to control the epithelial differentiation of synovial sarcoma precursor cells through affecting some different target genes or the same genes at different levels.
