Clinical and pathological characteristics of head and neck malignant melanoma
10.3760/j.issn:0253-3766.2001.03.027
- VernacularTitle:头颈部恶性黑色素瘤的临床及病理研究
- Author:
Dingtai LUO
1
;
Heshun XIA
Author Information
1. Hubei Cancer Hospital
- From:
Chinese Journal of Oncology
2001;23(3):256-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and pathogical characteristics of head and neck malignant melanoma. Methods Sixty-eight cases of head and neck malignant melanoma were reviewed. There were 33 patients with melanoma in the nasal cavity and oral cavity, 35 patients with melanoma in the skin. The age fastigium of the patients was from 41 to 60 years. Surgical specimens in 52 cases and biopsy specimens in 16 cases were studied pathologically. S-100, HMB45 and NSE were examined immunohistochemically.ResultsHistopathology studies showed that the cell mosphology was pleomophic as well as polymorphic both in shape and size of the cells. Immunohistochemical studies helped diagnosis as all of the 42 melonoma specimens were positure for S-100 and 90.5% positive for HMB45. In 52 of the 68 cases, the tumor was excised surgically, with additional radiotherapy in 13 cases or chemotherapy in 21 cases. Ten cases were treated with radiotherapy alone. In 56 patients followed-up, 12 survived for 5 years, including 9 cases of skin melanoma and 3 cases of nasal and oral melanoma.Conclusion The histo-pathological features of malignant melanoma vary significally. Immunohistochemical staining helps diagnosis and differential diagnosis.The prognosis of malignant melanoma in nasal cavity and oral cavity is poor as compared to that in the skin of head and neck region.
