The prognostic value of BAP1 protein loss in patients with malignant mesothelioma
10.3760/cma.j.cn121094-20240112-00016
- VernacularTitle:BAP1蛋白表达缺失对恶性间皮瘤患者的预后价值研究
- Author:
Yiqiu CHEN
1
;
Zhibin GAO
;
Wei SHEN
;
Shibo YING
;
Xianglei HE
;
Xing ZHANG
;
Zhaoqiang JIANG
;
Jianlin LOU
Author Information
1. 杭州医学院公共卫生学院，杭州 310000
- Keywords:
Mesothelioma;
Malignant mesothelioma, MM;
BRCA1-associated protein 1, BAP1;
Asbestos;
Prognosis;
Immunohistochemistry
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(11):815-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic value of BRCA1-associated protein 1 (BAP1) expression loss in patients with malignant mesothelioma (MM) .Methods:A total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis. Kaplan-Meier method was used to draw the survival curve, and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate.Results:Among 82 MM patients, 61 (74.4%) were female, aged (57±11) years. BAP1 protein expression was deficient in 39 patients (47.6%). The survival rate was correlated with the loss of BAP1 protein expression and age (χ 2=5.27, 5.66, P=0.022, 0.017). Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients <57 years of age, female, pleural MM, epithelial MM, and treated with drugs or surgery ( P<0.05). Multivariate model results showed that positive expression of BAP1 protein ( HR=3.75, 95% CI: 2.23-6.30, P<0.001) and age ≥57 years ( HR=1.66, 95% CI: 1.01-2.72, P=0.049) were risk factors for survival in patients with MM. Conclusion:Loss of BAP1 protein expression may be an independent prognostic factor in patients with MM, which is associated with longer survival.
