Research progress on the regulatory mechanism of Hippo signaling pathway in pulmonary fibrosis
10.3760/cma.j.cn121094-20231111-00111
- VernacularTitle:Hippo信号通路在肺纤维化中的调控机制研究进展
- Author:
Ruixia DING
1
;
Ying SUN
;
Xiaohui WANG
Author Information
1. 内蒙古科技大学包头医学院公共卫生学院，包头 014040
- Keywords:
Pulmonary fibrosis;
Hippo signaling pathway;
Regulation mechanism;
Fibroblasts;
YAP/TAZ
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(9):716-720
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is a difficult to treat fibrotic disease with multiple triggering factors and complex pathogenesis. It is characterized by diffuse inflammatory damage, tissue structure destruction, and persistent fibrosis, resulting in irreversible damage to lung function. The Hippo signaling pathway is involved in regulating various biological processes such as cell proliferation, differentiation, migration, apoptosis, and is closely related to the occurrence of pulmonary fibrosis. In order to further explore the mechanism of pulmonary fibrosis, this paper comprehensively analyzes the Hippo signaling pathway and its cellular and pathological imbalance related to pulmonary fibrosis, revealing the influence of Hippo signaling pathway in pulmonary fibrosis and its possible mechanism of action, which is expected to provide new targets and strategies for the prevention and treatment of pulmonary fibrosis.
