The role of long non-coding RNA in the pathogenesis of pulmonary fibrosis of silicosis
10.3760/cma.j.cn121094-20220218-00077
- VernacularTitle:长链非编码RNA在矽肺纤维化发病机制中的作用研究
- Author:
Jiahui YAO
1
;
Jianlin LOU
Author Information
1. 杭州医学院公共卫生学院（浙江省医学科学院），杭州 310013
- Keywords:
Silicosis;
Long non-coding RNA;
Pulmonaryfibrosis;
microRNA;
Signaling pathway;
mRNA transcription
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(9):715-720
- CountryChina
- Language:Chinese
-
Abstract:
Silicosis is a progressive pulmonary fibrosis disease caused by long-term inhalation of a large amount of free crystalline silica, which seriously threatens the health of relevant workers and causes a huge amount of disease burden. The pathogenesis of silicosis is complex and unclear, it has been reported that long non coding RNA (lncRNA) plays an important role in the pathogenesis of silicosis. In order to improve the understanding of the disease and provide directions for the prevention and treatment of silicosis, this article reviewed the mechanism of lncRNA in the pathogenesis and disease progression of silicosis.
