Research progress on animal and cell models of pneumoconiosis
10.3760/cma.j.cn121094-20210425-00230
- VernacularTitle:尘肺病动物和细胞模型研究进展
- Author:
Runsu HOU
1
;
Yange TIAN
;
Jiansheng LI
Author Information
1. 河南中医药大学，呼吸疾病中医药防治省部共建协同创新中心，郑州 450046
- Keywords:
Pneumoconiosis;
Animal model;
Cell model;
Review
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(7):547-552
- CountryChina
- Language:Chinese
-
Abstract:
Pneumoconiosis is an occupational lung disease with the highest incidence in China. There is no effective treatment drug at present. Animal and cell models are the basis for exploring its pathogenesis and developing effective drugs. In this paper, we sort out the methods of animal models of pneumoconiosis and the different cell models induced by dust in recent years, by analyzing and summarizing the advantages and disadvantages, modeling time, pathology and changes in important indicators of different preparation methods of animal models, as well as different cell models induced by the dust to simulate different pathological models and pathological stages, to provide basis for the application and improvement of pneumoconiosis model.
