Analysis of the detection of metals and metalloids in the bronchoalveolar lavage fluid for the etiological diagnosis value of pneumoconiosis
10.3760/cma.j.cn121094-20201207-00672
- VernacularTitle:支气管肺泡灌洗液中金属及类金属浓度检测对尘肺病因学诊断的价值分析
- Author:
Weixia DUAN
1
;
Lvsu YE
;
Hang DU
;
Cong LIU
;
Yu DUAN
;
Longchun MAO
Author Information
1. 400060 重庆市职业病防治院实验医学中心，重庆医药高等专科学校附属第一医院职业病防治与中毒救治重庆市重点实验室
- Keywords:
Pneumoconiosis;
Bronchoalveolar lavage fluid;
Diagnosis;
Metals;
Etiological
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(11):844-848
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the differences of the concentrations of metals and metalloids in bronchoalveolar lavage fluid (BALF) of patients with pneumoconiosis, so as to provide reference for the etiological diagnosis of pneumoconiosis.Methods:From September 2019 to August 2020, 47 pneumoconiosis patients hospitalized in Chongqing Prevention and Treatment Center for Occupational Diseases and undergoing bronchoalveolar lavage were selected as the research objects using cluster sampling method. The general situation and occupational history of patients were investigated by questionnaire, The BALF of 47 pneumoconiosis patients was collected, and the concentrations of metals and metalloids in BALF were detected by inductively coupled plasma mass spectrometry (ICP-MS) , the differences among patients with different types of pneumoconiosis, different stages of silicosis and different occupational history were analyzed by one-way ANOVA.Results:The concentrations of 50 metals and metalloids in BALF were detected, and 21 of them were analyzed. Compared with different types of pneumoconiosis, the concentrations of Zn, Mn and Sn in BALF were statistically significant ( F=9.959, 3.635, 9.488, P<0.05) . The concentrations of K, Mg, Fe, Zn, Cu and Ni in BALF were significantly different in different stages of silicosis ( F=4.271, 4.334, 3.588, 5.120, 7.340, 3.905, P<0.05) . The concentrations of Zn and Sn in pneumoconiosis patients with different types of work and types of exposed dust were significantly different ( P<0.05) . Conclusion:The detection of Zn, Mn, Sn, and other metals in BALF can provide reference basis for the etiological diagnosis of pneumoconiosis and provide a new idea for the diagnostic method of pneumoconiosis.
