Four cases of acute diquat poisoning with prominent epileptoid seizure and literature review
10.3760/cma.j.cn121094-20200224-00078
- VernacularTitle:以癫痫样发作为突出表现的急性敌草快中毒四例并文献复习
- Author:
Xianglong CAI
1
;
Fei TENG
;
Xin YU
;
Liangliang LIU
;
Guoqiang LI
Author Information
1. 300162 天津，武警特色医学中心综合重症医学科
- Keywords:
Diquat;
Poisoning;
Clinical features;
Epileptoid seizure;
Literature review
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(5):359-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To further improve the awareness of the clinical feature of acute diquat poisoning.Methods:A retrospective analysis was performed on 4 cases of acute diquat poisoning with epileptoid seizure as the main clinical manifestation, which were admitted and diagnosed by the Characteristic Medical Center of Chinese People's Armed Police Force from January 1, 2017 to December 31, 2019. Take "Diquat" or "Deiquat" or "Reward" as keyword search for CNKI, Pubmed, and EMbase in both Chinese and English. The date of literature retrieval was from the database founding to December 31, 2019.Results:Of the 4 patients, 3 were male and 1 female, with an average age of 28 years (22-33 years) . The estimated dose was 8-20 g. All patients were treated with gastric lavage, catharsis, fluid replacement, blood perfusion, and in the early stage of treatment of epileptic seizures, the initial routine antiepileptic drugs had poor effect. Then propofol and midazolam were injected into the treatment. The epilepsy was relieved, but the condition deteriorated rapidly, and the patients died eventually. The literature search retrieved 3 patients in the 3 literatures included in the study were analyzed, and their clinical course was similar to that of 4 cases in the center. Necropsy was performedon all 3 patients, and the results were cerebral edema, diffuse cerebral edema, and hemorrhage around the basal ganglia.Conclusion:Acute diquat poisoning can cause epileptic seizures. Once it occurs, the disease progresses rapidly and the prognosis is poor. The combination of large dose of sedative drugs can be used to treat epilepsy in order to improve the prognosis.
