Research progress of pyroptosis in respiratory diseases
10.3760/cma.j.cn121094-20190419-00158
- VernacularTitle:细胞焦亡在呼吸系统疾病中的研究进展
- Author:
Xu YANG
1
;
Shan SHAN
;
Zhongjun DU
Author Information
1. 250062 济南，山东省职业卫生与职业病防治研究院；271000 泰安，山东第一医科大学（山东省医学科学院）公共卫生学院
- Keywords:
Cell death;
Respiratory diseases;
Pyroptosis;
Inflammasomes
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(11):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed death mode dependent on Caspase-1/4/5/11, which is caused by activation of inflammasome, accompanied by cell membrane rupture, pore formation and cell content release. As a new type of cell death, it is widely involved in respiratory diseases, such as pulmonary fibrosis, acute lung injury, bronchopulmonary dysplasia, chronic obstructive pulmonary disease and asthma. This article reviews the mechanism of pyroptosis and its role in different respiratory diseases, in order to provide new ideas for the treatment of respiratory diseases.
