The discussion of the correlation between tumor necrosis factor-alpha and aquaporin 4 expression in critical poisoning brain edema

VernacularTitle:重症中毒脑水肿肿瘤坏死因子α对水通道蛋白4表达相关性的探讨
Author: Yuelei CHENG ¹ ; Jian LIU ; Meng LI
Author Information

1. 271000　泰安，山东第一医科大学第二附属医院急诊医学科，山东省临床中毒研究重点实验室
Keywords: Brain edema; Critical poisoning; Tumor necrosis factor-alpha; Aquaporin 4
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2020;38(7):553-555
CountryChina
Language:Chinese
Abstract: Critical poisoning is a critical illness. Cerebral edema after poisoning is one of the important factors that cause the patient's condition to worsen and affect the prognosis of patients after acute brain injury. Aquaporin 4 (AQP-4) is an important member of the aquaporin family and is abundantly expressed in the central nervous system, playing a pivotal role in the formation of cerebral edema. Brain injury can cause the secretion of inflammatory transmitters, causing or aggravating cerebral edema. Tumor necrosis factor-alpha (TNF-α) has been confirmed to be most closely related to cerebral edema, and can participate in the formation and development of brain edema by regulating AQP-4.