Association between PON2 gene polymorphisms and susceptibility to noise-induced hearing loss
10.3760/cma.j.issn.1001-9391.2020.02.011
- VernacularTitle:PON2基因多态性与噪声性听力损失易感性的关系
- Author:
Shanshan WU
1
;
Jinning YU
;
Jie JIAO
;
Guoshun CHEN
;
Changyun ZHANG
;
Shanfa YU
Author Information
1. 266071 青岛，中国石油化工股份有限公司青岛安全工程研究院
- Keywords:
Hearing Loss, Noise;
Susceptibility;
PON2;
Single ruccleotide polynonphisms
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(2):128-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between SNP and noise-induced hearing loss (NIHL) susceptibility in occupational noise exposure population in China.Methods:From 6297 for a certain steel works in contact with noise, contact length of 3 years or more and workplace noise exposure intensity of 80 dB (A) , ears or high frequency (3 000, 4 000, 6 000 Hz) average of hearing acuity 40 dB (HL) , or high frequency loss in both ears, on the basis of single whisper frequency (500, 1, 000, 2 000 Hz) average threshold of 26 dB (HL) or object as case group. A case-control study was designed with 1:1 matching. Subjects with the same gender, the same type of work, age ±5 years old, and working age ±2 years after noise exposure were selected as the control group. Subjects with any whisper frequency (500, 1, 000, 2, 000 Hz) whose hearing threshold in any frequency band was ≤25 dB (A) and whose average high-frequency hearing threshold in pure tone hearing test was <35 dB (A) were selected as the control group. Four sites of PON2 gene were genotyped by medium-and high-throughput SNP genotyping. Univariate logistic regression was used to analyze the relationship between single SNP polymorphism and NIHL.Results:A total of 286 case-control pairs were included. Smoking was statistically significant difference between cases and controls ( P<0.001) . Conclusion:No statistical difference has been found between single SNP polymorphism and NIHL. At the level of greater than 92 dB of high noise exposure, rs7785846 (CT+TT) genotype is a risk factor for occupational noise deafness, and its OR is 2.74 (95% CI: 1.09-6.89) compared with wild homozygous type (CC) . Conclusion. The rs7785846 (CT+TT) genotype carriers of PON2 gene are more susceptible to hearing impairment when exposed to high noise intensity.
