The research of proteome profiling change of 1-bromopropane poisoning cases

VernacularTitle:1-溴丙烷中毒患者蛋白质谱变化的研究
Author: Rongming MIAO ¹ ; Bangmei DING ; Yingyi ZHANG ; Weimin WU ; Dehong YOU ; Zonghua FANG ; Rui ZHAO
Author Information

1. 214011,无锡市第八人民医院
Keywords: 1-bromopropane; Poisoning; Occupational diseases
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2016;34(11):835-838
CountryChina
Language:Chinese
Abstract: Objective This study was mainly focused on styudy on he proteome profile change between exposure to 1-Bromopropane (1-BP) and 1-BP poisoning.Methods The samples of serums from exposure to 1-BP and 1-BP poisoning were collected and analyzed through Label free proteome technology platform.The differently expressed proteins between the two groups were quantified and identified,followed by function analysis by bioinformatics.Results 127 proteins over 2 fold-change were selected,in which 39 proteins were up-regulated and 88 proteins were down-regulated.These differently expressed proteins were mainly involved in the process of enzyme active regulation,inflammatory reaction,protein modification,stress response,coagulation,transport.Conclusion The differently expressed proteins provided the potential protein biomarkers for the early diagnosis of 1-BP poisoning and was beneficial for clinical diagnosis of 1-BP and understanding of the mechanism of 1-BP poisoning.