The relationships of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) inhalational dose and oxidative damage in foundry workers
10.3760/cma.j.issn.1001-9391.2016.09.003
- VernacularTitle:铸造工人PCDD/Fs接触水平与氧化损伤的关系
- Author:
Jintong HE
1
;
Sukun ZHANG
;
Ming ZHAO
;
Zhuang ZHANG
;
Tingming SHI
;
Weihong CHEN
Author Information
1. 430030武汉,华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系,环境与健康教育部重点实验室
- Keywords:
Occupational exposure;
Polychlorinated dibenzo-p-dioxin and dibenzofurans;
8-oxo-deoxyguanosine;
8-Isoprostaglandin F2α
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(9):647-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage to DNA and lipid in foundry workers.Methods The participants were divided into three groups,including exposure group,administrator group and control group.The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in air environment were determined by isotope dilution high resolution capillary column gas chromatography/high resolution mass spectrometry (HRGC-HRMS).The inhalational dose of PCDD/Fs were evaluated by Houmen's model.Urinary 8OHdG was analyzed by high performance liquid chromatography-electrochemical detector (HPLC-ECD).Urinary 8-iso-PGF2a were determined by ELISA.Results The PCDD/Fs environmental concentrations of three groups (pg· TEQ/m) were 0.21 +0.08,0.03 ±0.01,0.0012 ±0.0007 (P＜0.05),respectively.The inhalational dose of exposure group (92.54 (32.90～264.49) fg· TEQ/kg· d) was 5.4 folds higher than the administrator group,and was 201 times more than control group.The levels of urinary 8-OHdG(nmol/L crea) of three groups were 3.25 (1.07～15.36),2.72(0.75～16.07),2.17(0.38～17.07) (P＜0.05) and the levels of urinary 8-iso-PGF2n (nmol/L crea)were 19.11(9.33～76.50),20.95(8.40～79.31),11.48(4.85～37.80)(P＜0.05),respectively.The multiple linear regression analysis revealed that there were significantly increased trend for levels of urinary 8-OHdG and 8-iso-PGF2a as PCDD/Fs exposure levels increased,after adjustment for age,sex,smoking statue,alcohol use and BMI (P＜0.01).Conclusion There was a dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage in foundry workers.
