Pathological changes in Purkinje cells of the cerebellum in acrylamide-intoxicated Ola mice and 6J mice
10.3760/cma.j.issn.1001-9391.2001.02.007
- VernacularTitle:丙烯酰胺中毒Ola和6J鼠小脑Purkinje细胞的病理改变
- Author:
Qiuyue HE
1
;
Manfu HAN
;
Mingli RAO
Author Information
1. Shenzhen Red Cross Hospital
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2001;19(2):102-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the differential pathological changes in Purkinje cells of the cerebellum in Ola mice and 6J mice after acrylamide intoxication. Methods Purkinje cells were studied by light microscope and electron microscope. Results Under light microscope,Purkinje cells in 6J mice were densely stained and irregular in cell shape.Under electron microscope,parts of the plasma membrane projection containing some smooth tubular endoplasmic reticula were found occasionally,and the membrane became split and thickened.These abnormal changes were not found in Ola mice. Conclusion Acrylamide intoxication may induce pathological changes in Purkinje cells of 6J mice which may be the pathological basis of ataxia.
