Influence of drinking on urinary excretion of 2-thiothiazolidine-4-carboxylic acid
10.3760/cma.j.issn.1001-9391.2000.06.012
- VernacularTitle:饮酒对尿2 -硫代噻唑烷-4-羧酸排泄的影响
- Author:
LE JIAN
1
Author Information
1. 浙江大学
- Keywords:
Carbon disulfide(CS2);
2-thiothiazolidine-4-carboxylic acid(TTCA);
Drinking
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2000;18(6):357-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of drinking alcohol or beer on excretion characteristics of urinary 2-thiothiazolidine-4-carboxylic acid(TTCA) in peoples exposed to carbon disulfide( CS2) and non-exposure ones. Methods (1)Ten male non-exposure volunteers drank 150 ml or 250 ml hquor(38°) within half an hour, and the excretion dynamic of urinary TTCA were detected with high performance liquid chromatograph. (2) Questionnarie and urine TTCA test were conducted in 152 male workers(end-shift urine) exposed to CS2 and 60 male control peoples(early morning urine).The ambient air at workplace was collected with active personal air monitoring and measured with a gas chromatograph. Results Urinary TTCA levels in non-exposure volunteers reached a high peak after 3 hours of drinking 150 ml liquor, and 12 hours later returned to the levels bofore drinking, the me dian of TTCA bofore drinking, after drinking 1,3 and 12 hours were 0.045,0.068,0.099 and 0.046 mg/g Cr( n =10) ,respectively.TTCA contents were in accordance with the alcohol consumption, the median of TTCA after 3 hours of drinking 0,125 or 250 ml hquor were 0.036,0.064,0. 609 mg/g Cr( n = 5), respectively. There were in creasing tendency of urine TTCA levels in workers exposed to different concentrations of CS2( ≤10.0 mg/m3, 10.1～50.0 mg/m3, > 50.0 mg/m3). When TTCA values were compared with drinking habit in various exposure situation,TTCA levels in people having drinking habit seemed higher( both liquor or beer) in non-exposure group and lower in exposure group, especially in high concentration group ( > 50.0 mg/m3 ). Conclusion Drinking large quantity of liquor may interfere the levels of urinary TTCA. Thus, in biomonitoring of CS2 the suitable sampling time is important to avoid the bias estimation of CS2 exposure.
