High expression of CREM is associated with poor prognosis in gastric cancer patients
10.12122/j.issn.1673-4254.2024.09.18
- VernacularTitle:CREM在胃癌中高表达并与患者的不良预后相关
- Author:
Mengnan YE
1
,
2
;
Hongmei WU
;
Yan MEI
;
Qingling ZHANG
Author Information
1. 华南理工大学医学院,广东 广州 510006
2. 南方医科大学附属广东省人民医院(广东省医学科学院)病理科,广东 广州 510080
- Keywords:
gastric cancer;
CREM;
bioinformatics;
immunohistochemistry;
prognosis
- From:
Journal of Southern Medical University
2024;44(9):1776-1782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of CREM in gastric cancer(GC)and its correlation with prognosis of the patients.Methods TCGA and GEO databases were used to analyze the expression levels of CREM mRNA in GC and adjacent tissues.Immunohistochemistry was used to examine the expression of CREM protein in 43 pairs of GC and adjacent tissues,and the correlation of CREM expression with clinicopathological features of the patients was analyzed.Kaplan-Meier survival analysis was used to explore the relationship between CREM expression and survival of GC patients.LinkedOmics database was used to annotate the GO function and KEGG pathway enrichment of CREM-related genes.Results Database analysis showed that CREM was highly expressed in GC tissues(P<0.05)and positively correlated with poor prognosis in GC patients(P=0.01).Immunohistochemistry results showed significantly higher CREM expression in GC tissues than in paired adjacent tissues(P<0.0001),and its expression level was correlated with T-stage and N-stage of the tumor(P<0.05).The overall survival of GC patients with high expression of CREM was shorter(RR=4.02,P=0.0046).Gene enrichment analysis showed that high CREM expression promotes occurrence and progression of GC very likely through the cell adhesion signaling pathway.Conclusion CREM is highly expressed in GC,and its high expression is associated with a poor prognosis of GC patients,suggesting the potential of CREM to serve as a prognostic indicator for GC.
