Effects of type 2 inflammation on bronchodilator responsiveness of large and small airways in chronic obstructive pulmonary disease
10.12122/j.issn.1673-4254.2024.01.11
- VernacularTitle:2型炎症对慢阻肺大、小气道支气管舒张反应性的不同影响
- Author:
Guiling XU
1
;
Zhaoqian GONG
;
Junrao WANG
;
Yanyan MA
;
Maosheng XU
;
Meijia CHEN
;
Dapeng HU
;
Jianpeng LIANG
;
Wengqu ZHAO
;
Haijin ZHAO
Author Information
1. 南方医科大学南方医院呼吸与危重症医学科,慢性气道疾病实验室,广东 广州 510515
- Keywords:
type 2 inflammation;
chronic obstructive pulmonary disease;
bronchodilator responsiveness;
small airway
- From:
Journal of Southern Medical University
2024;44(1):93-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of type 2 inflammation markers blood eosinophils(EOS)and fractional exhaled nitric oxide(FeNO)on bronchodilator responsiveness(BDR)in patients with chronic obstructive pulmonary disease(COPD).Methods This study was conducted among 389 patients with an established diagnosis of COPD in our hospital from October,2019 to October,2023,who all underwent bronchial dilation test(BDT)of the large and small airways.Based on smoking history,blood EOS,and FeNO,these patients were divided group A(blood EOS<300/μL+FeNO<35 ppb+smoking history<20 pack-years),group B(blood EOS<300/μL+FeNO<35 ppb+smoking history≥20 pack-years),group C(blood EOS≥300/μL or FeNO≥35 ppb+smoking history≥20 pack-years),and group D(blood EOS≥300/μL or FeNO≥35 ppb+smoking history<20 pack-years)for analyzing the relationship between clinical indexes and BDR.Results BDR evaluation based on forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and maximum mid-expiratory flow(MMEF)yielded consistent results,all showing a younger mean age,higher FeNO levels,and higher blood EOS counts and percentages in patients positive for BDT(P<0.05).The improvement value and improvement rate of FEV1 were significantly lower in group A than in group D.The improvement value and improvement rate of FEV1 as well as the improvement rate of MMEF were significantly lower in group B than in group D.In the overall patients,age and FeNO were significantly correlated with the improvement value and improvement rate of FEV1 and the improvement rate of MMEF(P<0.05).Conclusion Type 2 inflammation markers have different effects on BDR in the large and small airways of COPD patients,and their clinical significance needs further investigation.
