Association between HLA-A and HLA-DRB1 allele polymorphisms and susceptibility to tuberculosis in southern Chinese population
10.3969/j.issn.1673-4254.2018.01.015
- VernacularTitle:HLA-A、HLA-DRB1等位基因多态性与中国南方活动性肺结核患者遗传易感性的相关性
- Author:
Chunxin LIAO
1
;
Jiahui YANG
;
Jinli WANG
;
Xialin DU
;
Ruining WANG
;
Shimeng ZHANG
;
Wenting HE
;
Qian WEN
;
Li MA
Author Information
1. 广东省广州市胸科医院内科
- Keywords:
tuberculosis;
HLA gene;
gene frequency;
susceptible gene
- From:
Journal of Southern Medical University
2018;38(1):95-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between HLA allele frequencies in peripheral blood mononuclear cells (PBMCs) and the susceptibility to tuberculosis in southern Chinese population. Methods The polymorphisms of HLA-A and HLA-DRB1 loci in the PBMCs were analyzed in 294 patients with active tuberculosis using polymerase chain reaction-sequence based typing (PCT-SBT). The allele frequencies in the patients were compared with the data from 644 control southern Chinese subjects obtained from the online database Allele Frequencies in Worldwide Population. Results The frequencies of HLA-A*0101 and HLA-DRB1*1454 alleles in the patient cohort with pulmonary tuberculosis were significantly higher than those in the control group (2.4％vs 0.6％,χ2=10.788, P=0.001, Pc=0.016;7.5％vs 0％,χ2=69.850, P<0.0001);the frequencies of HLA-DRB1*1202 and HLA-DRB1*1401 alleles were significantly lower in this patient cohort than in the control group (10.4％vs 16.1％,χ2=9.845, P=0.002, Pc=0.044;0％vs 3.1％,χ2=18.520, P<0.001). Conclusion The frequencies of HLA-A and HLA-DRB1 alleles are correlated with the susceptibility to active tuberculosis in this southern Chinese population. HLA-A*0101, HLA-DRB1*1454 and the other 3 alleles are likely susceptible genes to tuberculosis, while HLA-DRB1*1202, HLA-DRB1*1401 and the other 4 alleles can be protective genes in this population.
