Sinogram restoration for low-dose cerebral perfusion CT images
10.3969/j.issn.1673-4254.2017.04.08
- VernacularTitle:投影数据恢复方法在低剂量脑灌注CT成像中的应用
- Author:
Xiumei TIAN
1
;
Jing HUANG
;
Jiahui LIN
;
Xinyu ZHANG
;
Jianhua MA
;
Zhaoying BIAN
Author Information
1. 南方医科大学生物医学工程学院//广东省医学图像处理重点实验室
- Keywords:
low-dose;
cerebral perfusion computed tomography;
sinogram restoration;
penalized weighted least-square
- From:
Journal of Southern Medical University
2017;37(4):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective In clinical cerebral perfusion CT examination, repeated scanning the region of interest in the cine mode increases the radiation dose of the patients, while decreasing the radiation dose by lowering the scanning current results in poor image quality and affects the clinical diagnosis. We propose a penalized weighted least-square (PWLS) method for recovering the projection data to improve the quality of low-dose cerebral perfusion CT imaged. This method incorporates the statistical distribution characteristics of brain perfusion CT projection data and uses the statistical properties of the projection data for modeling. The PWLS method was used to recover the data, and the Gauss-Seidel (GS) method was employed for iterative solving. Adaptive weighting is introduced between the original projection data and the projection data after PWLS restoration. The experimental results on the clinical data demonstrated that the PWLS-based sinogram restoration method improved noise reduction and artifact suppression as compared with the conventional noise reduction methods, and better retained the edges and details to generate better cerebral perfusion maps.
