Expression of asparagine synthetase in relapsed or refractory extranodal NK/T cell lymphoma
10.3969/j.issn.1673-4254.2017.04.07
- VernacularTitle:天冬酰胺合成酶在复发/难治的结外NK/T细胞淋巴瘤中的表达及临床意义
- Author:
Shaojie WU
1
;
Yufa LI
;
Yujue WANG
Author Information
1. 南方医科大学珠江医院血液科
- Keywords:
relapsed/refractory extranodal NK/T cell lymphoma;
asparagine synthetase;
asparaginasum;
chemotherapy
- From:
Journal of Southern Medical University
2017;37(4):465-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression level of asparagine synthetase (ASNS) in patients with relapsed or refractory extranodal NK/T cell lymphoma and explore its clinical significance. Methods Ten patients with relapsed or refractory extranodal NK/T cell lymphoma admitted in our department from January, 2013 to January, 2016 were analyzed. The diagnoses were confirmed by pathological and immunohistochemical examination following failed chemotherapies in all cases. Branched DNA-liquidchip technique (bDNA-LCT) was used for detecting ASNS mRNA expression in paraffin-embedded tissue sections in the 10 cases of relapsed or refractory extranodal NK/T cell lymphoma and in 5 cases of chronic rhinitis. The correlations were analyzed between ASNS expression and the clinicopathological features and outcomes of the patients with failed chemotherapy regimens containing asparaginasum. Results Six out of the 10 patients with relapsed or refractory extranodal NK/T cell lymphoma died due to diseaseprogression. The expression level of ASNS was significantly higher in the lymphoma tissues than in tissue specimens of chronic rhinitis (P<0.05). The expression level of ASNS was associated with the International Prognostic Index (P=0.023) in patients with relapsed or refractory extranodal NK/T cell lymphoma, and Kaplan-Meier curve showed that a high ASNS expression was correlated with a reduced overall survival and progression-free survival of the patients. Conclusion Asparaginasum-based chemotherapy regimens are recommended for treatment of relapsed or refractory extranodal NK/T cell lymphoma with low ASNS expressions.
